The snuff smoking is the main cause in 90% of cases of lung cancer in both men and women. Decades ago, this tumor was much less common in women and it was featured it was more likely that was not related to snuff. These differences are disappearing rapidly, reflecting the incorporation of women with smoking in the previous years.

Another part of this type of cancer is caused by inhaled substances and who are in the workplace, a phenomenon related to the 10% -15% of lung cancer in males and 5% in women. The most important of these substances are asbestos, such as those used in asbestos factories.

Lung cancer can also be caused by radiation received at the chest, such as treatment with radiation therapy used to treat breast cancer and lymphoma. The interval between radiation exposure and cancer onset is usually very long, around age 20. The greatest risk are people who tried for many years with old appliances, and smoked during the following years. The risk with modern radiotherapy equipment is very low.

Hereditary factors have little relation to lung cancer.