Cancer Information

An article published this week reveals how researchers at Caltech have managed to “turn off” genes that force cancer cells to grow uncontrollably. This is the first time in humans is achieved using an RNAi therapy. As explained in immortal and perfect (p95, p217), the RNAi is small RNA able to specifically block the function of a gene. Are widely used in the laboratory but so far not been proven effective as therapy.

So far the technique has been tested only in 15 patients with melanoma by injecting the RNAi in the blood. We have seen that in some cases selected genes get turned off and even decrease the levels of the protein that make these genes, although it is unclear whether the net effect is that the tumor disappears. They have already started more complete clinical trials to verify it is a technique as effective and safe. It is a very promising step forward, although still preliminary, which opens up interesting perspectives for a whole new type of cancer treatment.

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